Take simvastatin once a day in the evening. This is because your body makes most cholesterol at night. Simvastatin doesn't upset the stomach, so you can take it with or without food. Simvastatin at Night According to a study published in the British Medical Journal in October 2003, simvastatin is more effective when you take it in the evenings before bed rather than in the morning or during the day. You can take simvastatin before or after food. Do not drink grapefruit juice at any time while you are taking simvastatin. This is because a chemical in grapefruit juice increases the amount of simvastatin in your bloodstream. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Participants, methods, and results. We randomised adults stable on 10 or 20 mg of simvastatin at night for primary or secondary prevention of coronary heart disease, stroke, or peripheral vascular disease, to dosings in the morning or evening for a period of eight weeks. Comment. Simvastatin is probably best taken at night because concentrations of total cholesterol and of low density lipoprotein are significantly greater when it is taken in the morning. Simvastatin is generally in the system for 12 hours, after 12 hours the concentration drops. Cholesterol is made more extensively by the liver at night. It is most commonly recommended to take simvastatin at night, versus in the morning. This recommendation is true for most statin drugs, but not all. We'll explain why you should take some statins at night, while some other types can be taken in the morning. Here's what you should know. Here's what you should know. Sim crosses the blood brain barrier and can cause insomnia. So i take it in the morning then i can sleep at night. Does anyone notice side effects from taking both alinia or simvastation.